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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CHEK2
All Species:
0
Human Site:
S12
Identified Species:
0
UniProt:
O96017
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O96017
NP_001005735.1
543
60915
S12
S
D
V
E
A
Q
Q
S
H
G
S
S
A
C
S
Chimpanzee
Pan troglodytes
XP_001172779
543
60866
Rhesus Macaque
Macaca mulatta
XP_001102484
543
60923
Dog
Lupus familis
XP_543464
544
61233
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z265
546
61070
Rat
Rattus norvegicus
NP_446129
545
60912
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508699
537
60493
Chicken
Gallus gallus
NP_001073576
522
58779
Frog
Xenopus laevis
NP_001082016
517
58243
Zebra Danio
Brachydanio rerio
Q501V0
422
47914
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O61267
476
54243
Honey Bee
Apis mellifera
XP_624334
480
54300
Nematode Worm
Caenorhab. elegans
Q9U1Y5
476
53320
Sea Urchin
Strong. purpuratus
XP_794585
480
52849
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P39009
513
58614
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99
89.3
N.A.
83.1
83.4
N.A.
74.4
67.5
59.6
28.1
N.A.
34
37.2
30.2
43.2
Protein Similarity:
100
99.8
99
93
N.A.
89.7
89.9
N.A.
82.1
77.9
73.1
41.9
N.A.
51.5
54.5
49.5
58.3
P-Site Identity:
100
0
0
0
N.A.
0
0
N.A.
0
0
0
0
N.A.
0
0
0
0
P-Site Similarity:
100
0
0
0
N.A.
0
0
N.A.
0
0
0
0
N.A.
0
0
0
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
28.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
47.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
100
0
0
0
0
0
0
0
100
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
100
0
% C
% Asp:
0
100
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
100
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
100
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
100
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
100
100
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
100
0
0
0
0
0
0
100
0
0
100
100
0
0
100
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
100
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _